Treatments for retinopathy of prematurity

Retinopathy of prematurity (ROP) is a major complication of the care and survival of very preterm infants. Although prevention clearly is better than treatment, but prevention currently is not possible, even with careful regulation of blood oxygen saturation in very preterm infants. This disease of very preterm infants was initially treated with cryotherapy to destroy vascular hyperproliferation that progresses to blindness. Laser photocoagulation then replaced cryotherapy as a more targeted and less destructive therapy with considerable success. Recent research has identified vascular endothelial growth factor (VEGF) as a major mediator of neovascularization, and intraocular injection of antibodies against VEGF is a promising new therapy for ROP. This therapy avoids the focal retinal dest…

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