Role of phospholipases A2 in diabetic retinopathy: in vitro and in vivo studies.

In conclusion, the present findings indicate that PLA2 upregulation represents an early step in glucose-induced alteration of BRB, possibly upstream of VEGF; thus, PLA2 may be an interesting target in managing diabetic retinopathy.
PMID: 24076420 [PubMed – as supplied by publisher] (Source: Biochemical Pharmacology)