Pathophysiology of neonatal acute bacterial meningitis.

Authors: Barichello T, Fagundes GD, Generoso JS, Elias SG, Simões LR, Teixeira AL
Neonatal meningitis is a severe acute infectious disease of the central nervous system (CNS) and an important cause of morbidity and mortality worldwide. The inflammatory reaction involves the meninges, the subarachnoid space and the brain parenchymal vessels and contributes to neuronal injury. It may lead to deafness, blindness, cerebral palsy, seizures, hydrocephalus or cognitive impairment in approximately 25% to 50% of survivors. Bacterial pathogens may reach the blood-brain barrier and be recognised by antigen-presenting cells through the binding of Toll-like receptors. They induce the activation of factor nuclear kappa B or mitogen-activated protein kinas pathways and subsequently up-r… …read more