LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

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LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

Nature 499, 7458 (2013). doi:10.1038/nature12345

Authors: Xiaomeng Wang, Sabu Abraham, Jenny A. G. McKenzie, Natasha Jeffs, Matthew Swire, Vineeta B. Tripathi, Ulrich F. O. Luhmann, Clemens A. K. Lange, Zhenhua Zhai, Helen M. Arthur, James W. B. Bainbridge, Stephen E. Moss & John Greenwood
Aberrant neovascularization contributes to diseases such as cancer, blindness and atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although many regulators of pathogenic angiogenesis have been identified, our understanding of this process is incomplete. Here we explore the transcriptome of retinal microvessels isolated from (Source: Nature)