Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration.


This article focuses on the involvement of directionally secreted RPE proteins in normal functioning of the retina and on the potential association of incorrect RPE protein secretion with development of AMD. Understanding the importance of RPE polarity and the correct secretion of essential structural and regulatory components emerge as critical factors for the development of novel therapeutic strategies targeting AMD.
PMID: 23663427 [PubMed – as supplied by publisher] (Source: J Cell Mol Med)