3,4 dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells

Conclusions
Compensatory angiogenic signalling may occur in neovascular AMD following treatment with bevacizumab. Here we show that DPE, both alone and in combination with bevacizumab, can reduce the secretion of angiogenin, a cytokine that has been upregulated following treatment with bevacizumab in RPE cells. Therefore, DPE may represent a possible therapeutic agent to be used in combination with bevacizumab for the treatment of neovascular AMD. (Source: British Journal of Ophthalmology)